Category: Staphylococcus infection

Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus.

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Chronic wound infections: the role of Pseudomonas aeruginosa and Staphylococcus aureus.
Expert Rev Anti Infect Ther. 2015 Mar 8;:1-9
Authors: Serra R, Grande R, Butrico L, Rossi A, Settimio UF, Caro…

Sternoclavicular septic arthritis due to methicillin-resistant Staphylococcus aureus in a patient with a suprapubic catheter.

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Sternoclavicular septic arthritis due to methicillin-resistant Staphylococcus aureus in a patient with a suprapubic catheter.

BMJ Case Rep. 2015;2015

Authors: Monteiro N, Moleiro F, Lérias G, Silva AM

Abstract
We report a case of a 74-year-old man who presented to the emergency department with a 1-week history of fever. He had a meatal stenosis and had a suprapubic catheter for 10 months, and had a recent hospitalisation for urosepsis with bacteraemia due to methicillin-resistant Staphylococcus aureus after manipulation of the catheter. Clinical examinations were performed in the emergency department and the patient was hospitalised with the diagnosis of recurrent urinary tract infection. The following day, we noticed the development of a mass in the left sternoclavicular joint with inflammatory signs and excruciating pain. Ultrasonographic findings led to the diagnosis of left sternoclavicular synovitis, and methicillin-resistant S. aureus grew in blood cultures leading to the diagnosis of sternoclavicular septic arthritis. Treatment with vancomycin and gentamicin was started and maintained for 4 weeks with complete resolution of symptoms and no complications or sequelae.

PMID: 25694643 [PubMed – in process]

Beneficial effect of chronic Staphylococcus aureus infection in a model of multiple sclerosis is mediated through the secretion of extracellular adherence protein.

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Beneficial effect of chronic Staphylococcus aureus infection in a model of multiple sclerosis is mediated through the secretion of extracellular adherence protein.

J Neuroinflammation. 2015 Feb 3;12(1):22

Authors: Kumar P, Kretzschmar B, Herold S, Nau R, Kreutzfeldt M, Schütze S, Bähr M, Hein K

Abstract
BackgroundBacterial infections have been assumed to worsen multiple sclerosis (MS) disease symptoms and to lead to increased neurodegeneration. However, the underlying biological mechanisms for these effects are complex and poorly understood. Here, we assessed the disease-modulating effects of chronic infection with Staphylococcus aureus, a common human pathogen, on the clinical course and the extent of neurodegeneration in experimental autoimmune encephalomyelitis (EAE), an animal model of MS.MethodsTo conduct this study, we established a persistent chronic infection in female Brown Norway rats by inoculating Staphylococcus aureus (S. aureus) bacteria in a subcutaneously implanted tissue cages.ResultsIn this study, we observed that the introduction of a localized S. aureus infection during the subclinical phase of EAE induced a chronic systemic inflammatory response, consisting of increased T- and B-cell counts and systemic production of proinflammatory cytokines. Unexpectedly, the S. aureus infection completely prevented the development of clinical EAE, and markedly reduced inflammatory infiltration and demyelination of the optic nerve, while it increased the number of surviving retinal neurons. Using a S. aureus strain that lacked the extracellular adherence protein (Eap), we determined that the extracellular adherence protein is at least partially responsible for the inhibitory effect of S. aureus infection on autoimmune inflammation of the central nervous system.ConclusionsOur results demonstrate for the first time that chronic infection with S. aureus has a beneficial effect on EAE, indicating a dual role of infection in the pathogenesis of MS. We also showed that secretion of Eap by S. aureus plays a major role in preventing autoimmune inflammation of the CNS. Moreover, we identified Eap as a factor responsible for this protective effect.

PMID: 25644616 [PubMed – as supplied by publisher]

Cow-to-cow variation in fibroblast response to a toll-like receptor 2/6 agonist and its relation to mastitis caused by intramammary challenge with Staphylococcus aureus.

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Cow-to-cow variation in fibroblast response to a toll-like receptor 2/6 agonist and its relation to mastitis caused by intramammary challenge with Staphylococcus aureus.
J Dairy Sci. 2015 Jan 15;
Au…

Spontaneous Septic Arthritis of the Lumbar Facet Caused by Methicillin-Resistant Staphylococcus aureus in an Otherwise Healthy Adolescent.

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Spontaneous Septic Arthritis of the Lumbar Facet Caused by Methicillin-Resistant Staphylococcus aureus in an Otherwise Healthy Adolescent.
Am J Orthop (Belle Mead NJ). 2014 Jul;43(7):325-7
Authors: …

Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition.

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Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition.

Antimicrob Resist Infect Control. 2014;3:19

Authors: Datta R, Kleinman K, Rifas-Shiman S, Placzek H, Lankiewicz J, Platt R, Huang SS

Abstract
BACKGROUND: Observational studies rarely account for confounding by indication, whereby empiric antibiotics initiated for signs and symptoms of infection prior to the diagnosis of infection are then viewed as risk factors for infection. We evaluated whether confounding by indication impacts antimicrobial risk factors for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) acquisition.
FINDINGS: We previously reported several predictors of MRSA and VRE acquisition in 967 intensive care unit (ICU) patients with no prior history of MRSA or VRE who had an initial negative screening culture followed by either a subsequent negative screening culture (controls) or positive screening or clinical culture (cases). Within and prior to this acquisition interval, we collected demographic, comorbidity, daily device and antibiotic utilization data. We now re-evaluate all antibiotics by medical record review for evidence of treatment for signs and symptoms ultimately attributable to MRSA or VRE. Generalized linear mixed models are used to assess variables associated with MRSA or VRE acquisition, accounting for clustering by ward. We find that exclusion of empiric antibiotics given for suspected infection affects 17% (113/661) of antibiotic prescriptions in 25% (60/244) of MRSA-positive patients but only 1% (5/491) of antibiotic prescriptions in 1% (3/227) of VRE-positive patients. In multivariate testing, fluoroquinolones are no longer associated with MRSA acquisition, and aminoglycosides are significantly protective (OR = 0.3, CI:0.1-0.7).
CONCLUSIONS: Neglecting treatment indication may cause common empiric antibiotics to appear spuriously associated with MRSA acquisition. This effect is absent for VRE, likely because empiric therapy is infrequent given the low prevalence of VRE.

PMID: 24932407 [PubMed]

Staphylococcus aureus and staphylococcal food-borne disease: an ongoing challenge in public health.

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Staphylococcus aureus and staphylococcal food-borne disease: an ongoing challenge in public health.
Biomed Res Int. 2014;2014:827965
Authors: Kadariya J, Smith TC, Thapaliya D
Abstract

Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses.

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Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses.

New Microbiol. 2014 Jan;37(1):113-8

Authors: Tinelli M, Monaco M, Maffezzini E, Cerri MC, Piazza M, Minoli L, Anesi A, Pantosti A

Abstract
A 42-year-old woman, living in a nursing home for the mentally disabled, with congenital ventricular septal defect and multiple comorbidities, developed endocarditis with vegetations of the interventricular septum and the right coronary aortic leaflet. The main feature of this case was the metastatic embolism leading to multiple and muscular abscesses. Methicillin-sensitive S. aureus, spa type 253 and ST30, producing toxin shock syndrome toxin-1 was isolated from blood cultures. The patient was initially treated with beta-lactam antibiotics without showing clinical response and subsequently with daptomycin and linezolid that improved the patient�s clinical symptoms. The effectiveness of treatment with daptomycin and linezolid was partly due to the ability of linezolid to reduce TSST-1 secretion. The portal of entry of the infection was not recognized. TSST-1 production by the strain might have favoured the formation of large cardiac vegetations and the subsequent metastatic dissemination to the muscles.

PMID: 24531180 [PubMed – in process]

Treatment of pseudomonas and Staphylococcus bronchopulmonary infection in patients with cystic fibrosis.

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Treatment of pseudomonas and Staphylococcus bronchopulmonary infection in patients with cystic fibrosis.
ScientificWorldJournal. 2013;2013:645653
Authors: Das RR, Kabra SK, Singh M
Abstract

A Case of Acute Pyogenic Sacroiliitis and Bacteremia Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus.

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A Case of Acute Pyogenic Sacroiliitis and Bacteremia Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus.
Infect Chemother. 2013 Dec;45(4):441-5
Authors: Kim S, Lee KL, Baek HL, Jang SJ,…

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