Category: Staphylococcus infection

Spontaneous Septic Arthritis of the Lumbar Facet Caused by Methicillin-Resistant Staphylococcus aureus in an Otherwise Healthy Adolescent.

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Spontaneous Septic Arthritis of the Lumbar Facet Caused by Methicillin-Resistant Staphylococcus aureus in an Otherwise Healthy Adolescent.
Am J Orthop (Belle Mead NJ). 2014 Jul;43(7):325-7
Authors: …

Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition.

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Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition.

Antimicrob Resist Infect Control. 2014;3:19

Authors: Datta R, Kleinman K, Rifas-Shiman S, Placzek H, Lankiewicz J, Platt R, Huang SS

Abstract
BACKGROUND: Observational studies rarely account for confounding by indication, whereby empiric antibiotics initiated for signs and symptoms of infection prior to the diagnosis of infection are then viewed as risk factors for infection. We evaluated whether confounding by indication impacts antimicrobial risk factors for methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE) acquisition.
FINDINGS: We previously reported several predictors of MRSA and VRE acquisition in 967 intensive care unit (ICU) patients with no prior history of MRSA or VRE who had an initial negative screening culture followed by either a subsequent negative screening culture (controls) or positive screening or clinical culture (cases). Within and prior to this acquisition interval, we collected demographic, comorbidity, daily device and antibiotic utilization data. We now re-evaluate all antibiotics by medical record review for evidence of treatment for signs and symptoms ultimately attributable to MRSA or VRE. Generalized linear mixed models are used to assess variables associated with MRSA or VRE acquisition, accounting for clustering by ward. We find that exclusion of empiric antibiotics given for suspected infection affects 17% (113/661) of antibiotic prescriptions in 25% (60/244) of MRSA-positive patients but only 1% (5/491) of antibiotic prescriptions in 1% (3/227) of VRE-positive patients. In multivariate testing, fluoroquinolones are no longer associated with MRSA acquisition, and aminoglycosides are significantly protective (OR = 0.3, CI:0.1-0.7).
CONCLUSIONS: Neglecting treatment indication may cause common empiric antibiotics to appear spuriously associated with MRSA acquisition. This effect is absent for VRE, likely because empiric therapy is infrequent given the low prevalence of VRE.

PMID: 24932407 [PubMed]

Staphylococcus aureus and staphylococcal food-borne disease: an ongoing challenge in public health.

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Staphylococcus aureus and staphylococcal food-borne disease: an ongoing challenge in public health.
Biomed Res Int. 2014;2014:827965
Authors: Kadariya J, Smith TC, Thapaliya D
Abstract

Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses.

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Staphylococcus aureus toxic shock syndrome toxin-1 endocarditis with muscular metastatic abscesses.

New Microbiol. 2014 Jan;37(1):113-8

Authors: Tinelli M, Monaco M, Maffezzini E, Cerri MC, Piazza M, Minoli L, Anesi A, Pantosti A

Abstract
A 42-year-old woman, living in a nursing home for the mentally disabled, with congenital ventricular septal defect and multiple comorbidities, developed endocarditis with vegetations of the interventricular septum and the right coronary aortic leaflet. The main feature of this case was the metastatic embolism leading to multiple and muscular abscesses. Methicillin-sensitive S. aureus, spa type 253 and ST30, producing toxin shock syndrome toxin-1 was isolated from blood cultures. The patient was initially treated with beta-lactam antibiotics without showing clinical response and subsequently with daptomycin and linezolid that improved the patient�s clinical symptoms. The effectiveness of treatment with daptomycin and linezolid was partly due to the ability of linezolid to reduce TSST-1 secretion. The portal of entry of the infection was not recognized. TSST-1 production by the strain might have favoured the formation of large cardiac vegetations and the subsequent metastatic dissemination to the muscles.

PMID: 24531180 [PubMed – in process]

Treatment of pseudomonas and Staphylococcus bronchopulmonary infection in patients with cystic fibrosis.

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Treatment of pseudomonas and Staphylococcus bronchopulmonary infection in patients with cystic fibrosis.
ScientificWorldJournal. 2013;2013:645653
Authors: Das RR, Kabra SK, Singh M
Abstract

A Case of Acute Pyogenic Sacroiliitis and Bacteremia Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus.

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A Case of Acute Pyogenic Sacroiliitis and Bacteremia Caused by Community-Acquired Methicillin-Resistant Staphylococcus aureus.
Infect Chemother. 2013 Dec;45(4):441-5
Authors: Kim S, Lee KL, Baek HL, Jang SJ,…

A rare case of acute epiglottitis due to Staphylococcus aureus in an adult.

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A rare case of acute epiglottitis due to Staphylococcus aureus in an adult.
Infect Dis Rep. 2012 Jan 2;4(1):e3
Authors: Harris C, Sharkey L, Koshy G, Simler N, Karas JA
Abstract
Epiglottitis h…

Lancing of a boil leading to severe invasive methicillin-sensitive Staphylococcus aureus infection in an adolescent.

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Lancing of a boil leading to severe invasive methicillin-sensitive Staphylococcus aureus infection in an adolescent.
BMJ Case Rep. 2013;2013(dec11_2)
Authors: Medows M, Sharma A
Abstract
A 10-…

Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection.

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Pathogenesis of Staphylococcus aureus necrotizing pneumonia: the role of PVL and an influenza coinfection.

Expert Rev Anti Infect Ther. 2013 Sep 27;

Authors: Löffler B, Niemann S, Ehrhardt C, Horn D, Lanckohr C, Lina G, Ludwig S, Peters G

Abstract
Only recently necrotizing pneumonia was defined as a specific disease entity that is caused by a Panton-Valentine leukocidin (PVL)-producing Staphylococcus aureus strain and is frequently preceded by an influenza infection. Necrotizing pneumonia is characterized by a sudden onset and rapid worsening of symptoms, leukopenia, airway hemorrhages, severe respiratory failure and a high mortality rate. Despite clear epidemiological data, the function of PVL in necrotizing pneumonia has been controversially discussed due to conflicting results from different disease models. Furthermore, there are many proposed mechanisms how a viral infection could facilitate and interact with a bacterial superinfection. In this review, we summarize current data from 43 clinical cases and results from various infection models on necrotizing pneumonia. We discuss the contribution of S. aureus PVL and a preceding influenza infection and present a concept of the pathogenesis of necrotizing pneumonia.

PMID: 24073746 [PubMed – as supplied by publisher]

Screening for Methicillin-Resistant Staphylococcus aureus (MRSA): Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 102

Screening for Methicillin-Resistant Staphylococcus aureus (MRSA): Future Research Needs: Identification of Future Research Needs From Comparative Effectiveness Review No. 102
Book. 2013 06 Authors: Noorani HZ, Adams E, Glick S, Webe…

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